Algoritmo computacional para determinar o perfil mínimo de marcadores moleculares que discriminam um conjunto de cultivares.

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Results of the Brazilian Osteosarcoma Treatment Group studies III and IV: Prognostic factors and impact on survival

Purpose To evaluate the impact of chemotherapy and surgery on the outcome of osteosarcoma (OS) of the extremities and to identify prognostic factors in Brazilian patients.Patients and Methods A total of 225 patients with metastatic and nonmetastatic OS of the extremities were enrolled and assessed in two consecutive studies designed and implemented by the Brazilian Osteosarcoma Treatment Group.Results the 5-year survival and event-free survival rates for the 209 assessable patients were 50.1% and 39%, respectively; for the 178 patients with nonmetastatic disease at diagnosis, the rates were 60.5% and 45.5%, respectively. the multivariate analysis showed that the following variables were associated with a shorter survival: metastases at diagnosis (P < .001), necrosis grades 1 and 2 (P = .046), and tumor size (P = .0071).Conclusion the overall 5- and 10-year survival rates were lower than the rates reported in North American and European trials. A pattern of advanced disease at diagnosis was often present, with a high proportion of patients having metastases (20.8%) and large tumor size (42.9%). However, these features were not necessarily associated with longer duration of prediagnostic symptoms. These findings were considered in the strategic planning of the current Brazilian cooperative study, with the aim of improving survival and quality of life of a large number of patients with OS.Universidade Federal de São Paulo, Inst Oncol Pediat, Grp Apolo Adolescente & Crianca Com Canc, BR-04023062 São Paulo, BrazilHosp Canc, Dept Pediat, São Paulo, BrazilUniv São Paulo, Hosp Clin São Paulo, Fac Med, São Paulo, BrazilSanta Casa Misericordia, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthopaed, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, São Paulo, BrazilHosp Clin Porto Alegre, Porto Alegre, RS, BrazilChildrens Hosp Los Angeles, Los Angeles, CA 90027 USAUniversidade Federal de São Paulo, Inst Oncol Pediat, Grp Apolo Adolescente & Crianca Com Canc, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthopaed, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, São Paulo, BrazilWeb of Scienc